OSCE 2nd December 2023
The following is the OSCE made to answer questions around my patient who's case report is in the following link: https://riddhibhalla25.blogspot.com/2023/12/25-year-old-female-with-fever.html Question 1 What is microRNA and how is it being used in the treatment of dengue MicroRNAs (miRNAs) are ~19–24 nt non-coding RNAs that post-transcriptionally regulate gene expression by binding to target messenger RNAs (mRNAs). miRNAs are expressed by all metazoans and plants, as well as by several DNA viruses, and function as regulators of cellular processes such as development, differentiation, growth, homeostasis, stress responses, apoptosis and immune activation https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3621958/ Cellular miRNAs are post-transcriptional regulators that could play a role in direct regulation of viral genes. Host miRNA expressions could either promote or repress viral replications. Induction of some cellular miRNAs could help the virus to evade the host immune response by
